It may be possible for science to determine the ultimate truth of the universe. It is just that we can never know such truth has been reached.
That is a small part of a long post in the “early days” of this blog.
Xenophanes, about 2500 years ago:
The certain truth there is no man who knows, nor ever shall be, about the gods and all the things whereof I speak. Yea, even if a man should chance to say something utterly right, still he himself knows it not — there is nowhere anything but guessing.
quoted in A History of Western Philosophy by Bertrand Russell, page 40